Anti-cancer actions of carnosine and the restoration of normal cellular homeostasis

Carnosine is a naturally occurring dipeptide found in meat. Alternatively it can be formed through synthesis from the amino acids, ?-alanine and L-histidine. has long been advocated for use as an anti-oxidant anti-glycating agent to facilitate healthy ageing, there have also reports of having anti-proliferative effects that beneficial actions against development number different cancers. able undertake multiple molecular processes, it's mechanism action therefore remains controversial - both tissues those associated with cancer or metabolic diseases. Here we review current understanding its mechanistic role physiological contexts, how this relates cancer. turns over rapidly body due presence serum tissue carnosinase enzymes however, so dietary supplement would require ingestion daily doses. Strategies are being developed based upon either resistance carnosine analogs enzymatic turnover, else supplementation, these potential therapeutic agents discussed.